JAK Inhibitors for Alzheimer’s? Head Injury 25 Years Later; Havana Syndrome Probe

A machine learning framework to evaluate relationships between disease pathology and biological processes that can be described by genes produced a list of 15 FDA-approved drugs that could be repurposed to treat Alzheimer’s; five were Janus kinase (JAK) inhibitors. (Nature Communications)

A phase II study of gamma frequency neuromodulation, a novel intervention using EEG-calibrated auditory and visual stimuli to evoke neural activity, showed improved memory, cognition, and functional abilities and reduced brain atrophy in patients with mild-to-moderate Alzheimer’s disease, Cognito Therapeutics announced.

APOE4 disrupted lipid metabolism, but its effects were reversed by choline supplements in cell experiments. (Science Translational Medicine)

Head injury was associated with an increased risk of dementia 25 years later and showed evidence of a dose-dependent relationship. (Alzheimer’s & Dementia)

The genoSCORE-LAB polygenic risk scoring test is now available to help physicians assess a patient’s risk of cognitive decline from Alzheimer’s disease, Cytox Ltd in England announced.

Four scientists won the $1.5-million Brain Prize for discoveries leading to drugs for migraine that block the calcitonin gene-related peptide (CGRP) pathway, the Lundbeck Foundation announced.

One in four Parkinson’s disease patients who completed an online survey said they had used cannabis in the past 6 months. (npj Parkinson’s Disease)

Spectral-domain optical coherence tomography was tied to long-term disability worsening in multiple sclerosis. (Neurology)

The Washington Post interviewed researchers about retinal changes that may foreshadow Alzheimer’s or Parkinson’s diseases.

A federal judge dismissed a lawsuit that challenged dementia tests for retired NFL players that includes race norms, a practice that may make it harder for Black athletes to qualify for settlement awards. (AP)

A CIA task force will investigate Havana syndrome, the “concussion without concussion” symptoms afflicting dozens of U.S. intelligence officials and diplomats in Cuba, China, and Russia. (New York Times)